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Issue 14, 2020
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Radical cyclization of 1,6-dienes with azobis(alkylcarbonitriles) on water under additive-free conditions

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Abstract

Without using any additives, a practical and eco-friendly methodology has been realized for the tandem double cyclization of 1,6-dienes with easily accessible azobis(alkylcarbonitriles) on water. This chemistry has mild reaction conditions, employing water as the sole solvent, with high regioselectivity and ease of scale-up. Moreover, this is the first example of 1,n-diene cyclization using azobis(alkylcarbonitriles) as a two-carbon unit for the construction of polycyclic skeletons.

Graphical abstract: Radical cyclization of 1,6-dienes with azobis(alkylcarbonitriles) on water under additive-free conditions

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Article information


Submitted
12 Jan 2020
Accepted
17 Jun 2020
First published
18 Jun 2020

Green Chem., 2020,22, 4593-4596
Article type
Paper

Radical cyclization of 1,6-dienes with azobis(alkylcarbonitriles) on water under additive-free conditions

Y. Liu, Y. Meng, X. Huang, F. Qin, D. Wu, Q. Shao, Z. Guo, Q. Li and W. Wei, Green Chem., 2020, 22, 4593
DOI: 10.1039/D0GC00140F

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