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Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

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Abstract

Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)–H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfully extended to imidazopyrimidine, imidazothiazole and indazole heterocycles showing the broadness of this useful approach.

Graphical abstract: Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

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Article information


Submitted
12 Jan 2020
Accepted
17 Mar 2020
First published
18 Mar 2020

Green Chem., 2020, Advance Article
Article type
Communication

Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

J. S. S. Neto, R. A. Balaguez, M. S. Franco, V. C. de Sá Machado, S. Saba, J. Rafique, F. Z. Galetto and A. L. Braga, Green Chem., 2020, Advance Article , DOI: 10.1039/D0GC00137F

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