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Soy protein and chitin sponge-like scaffolds: from natural by-products to cell delivery systems for biomedical applications

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Abstract

The increasing necessity of developing new devices for biomedical applications has added a growing social need of being environmentally respectful. In this work, we have shown that natural by-products from the food industry (soy protein and β-chitin) can be an excellent source of biomaterials to produce 3D scaffolds through simpler and cleaner processes. With the mixture of these two polymers, we have developed sponge-like scaffolds (SLS) with great physicochemical properties. Furthermore, a dialysis pre-conditioning step was enough to obtain negligible cytotoxicity in vitro. The predominant M2 macrophage profile, an elevated deposition of collagen fibres and the enhanced neovascularization capacity suggested excellent biocompatibility also in vivo. Moreover, these SLS were able to promote cell adhesion, proliferation and high loading capacity. Finally, h-MSCs 3D-cultured in these SLS released four times higher VEGF than h-MSCs seeded onto 2D plates. The green thinking strategy, properties and biocompatibility of this SLS highlight its potential as a cell delivery system for biomedical applications.

Graphical abstract: Soy protein and chitin sponge-like scaffolds: from natural by-products to cell delivery systems for biomedical applications

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Supplementary files

Article information


Submitted
08 Jan 2020
Accepted
06 Feb 2020
First published
06 Feb 2020

Green Chem., 2020, Advance Article
Article type
Paper

Soy protein and chitin sponge-like scaffolds: from natural by-products to cell delivery systems for biomedical applications

K. Las Heras, E. Santos-Vizcaino, T. Garrido, F. Borja Gutierrez, J. J. Aguirre, K. de la Caba, P. Guerrero, M. Igartua and R. M. Hernandez, Green Chem., 2020, Advance Article , DOI: 10.1039/D0GC00089B

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