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Direct C(sp3)–H acyloxylation of indolin-3-ones with carboxylic acids catalysed by KI

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Abstract

The first KI-catalyzed direct acyloxylation of indolin-3-ones with carboxylic acids has been developed using 30% aq. H2O2 as a green oxidant at room temperature. Through this strategy, various C2-acyloxy indolin-3-ones were obtained in up to 96% yield. Moreover, the C2-acyloxy indolin-3-ones can serve as versatile intermediates for the synthesis of nucleophilic 2-monoarylated indolin-3-ones and 3-ylidene indoles.

Graphical abstract: Direct C(sp3)–H acyloxylation of indolin-3-ones with carboxylic acids catalysed by KI

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Supplementary files

Article information


Submitted
30 Dec 2019
Accepted
04 Mar 2020
First published
04 Mar 2020

Green Chem., 2020, Advance Article
Article type
Communication

Direct C(sp3)–H acyloxylation of indolin-3-ones with carboxylic acids catalysed by KI

Y. Zhao, Y. Tang, X. Fei, F. Yang, Z. Cao, D. Duan, Q. Zhao, Y. Yang, M. Zhou and B. He, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC04446A

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