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Temperature-Controlled Regioselective Thiolation of 2-Indolylmethanols under Aqueous Micellar Conditions

Abstract

A sustainable and regioselective synthesis of highly functionalized indole-based sulfides from thiols and 2-indolymethanols is described. Notably, this reaction can be performed in presence of 5 mol% In(OTf)3 under aqueous micellar conditions using an inexpensive surfactant DBSA. This protocol offers several advantages including excellent regioselectivities, organic solvent-free, ease of scale-up and broad substrate scope.

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Article information


Submitted
04 Dec 2019
Accepted
15 Jan 2020
First published
15 Jan 2020

Green Chem., 2020, Accepted Manuscript
Article type
Communication

Temperature-Controlled Regioselective Thiolation of 2-Indolylmethanols under Aqueous Micellar Conditions

S. Zhu, Y. ZHANG, J. Luo, F. Wang, X. Cao and S. Huang, Green Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9GC04155A

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