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Site-selective 1,3-double functionalization of arenes using para-quinol, C–N, and C–C/C–P three-component coupling

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Abstract

A catalytic and site-selective approach has been demonstrated for dual functionalization of arenes via cross-coupling reactions of p-quinols with amines and isocyanides/phosphites. The strategy enables the production of a series of 3-amino-benzamides and 3-amino-arylphosphonates in good to excellent yields with complete control of regio- and chemo-selectivity. The reaction is highly viable in terms of its environmental benignity, simple operation method, and scalability. Initial mechanistic studies were also carried out to unveil the reaction pathways.

Graphical abstract: Site-selective 1,3-double functionalization of arenes using para-quinol, C–N, and C–C/C–P three-component coupling

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Article information


Submitted
29 Nov 2019
Accepted
23 Jan 2020
First published
25 Jan 2020

Green Chem., 2020, Advance Article
Article type
Communication

Site-selective 1,3-double functionalization of arenes using para-quinol, C–N, and C–C/C–P three-component coupling

S. Husen, A. Chauhan and R. Kumar, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC04103F

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