Jump to main content
Jump to site search


Electrochemical-induced regioselective C-3 thiomethylation of imidazopyridines via a three-component cross-coupling strategy

Author affiliations

Abstract

The electrochemical-induced regioselective C-3 thiomethylation of imidazopyridines has been initially accomplished via a three-component cross-coupling strategy using thiocyanate as the sulfur source and methanol as the methyl reagent. This protocol provides a green method for the thiomethylation of imidazopyridines without the need for any exogenous oxidants and metal catalysts under room temperature conditions. A wide range of functional groups were tolerated to produce regioselective C-3 thiomethylated products in high yields. Importantly, such an electrochemical-oxidation-induced thiomethylated reaction could be easily scaled up with excellent efficiency.

Graphical abstract: Electrochemical-induced regioselective C-3 thiomethylation of imidazopyridines via a three-component cross-coupling strategy

Back to tab navigation

Supplementary files

Article information


Submitted
27 Nov 2019
Accepted
16 Jan 2020
First published
27 Jan 2020

Green Chem., 2020, Advance Article
Article type
Communication

Electrochemical-induced regioselective C-3 thiomethylation of imidazopyridines via a three-component cross-coupling strategy

J. Wen, C. Niu, K. Yan, X. Cheng, R. Gong, M. Li, Y. Guo, J. Yang and H. Wang, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC04068D

Social activity

Search articles by author

Spotlight

Advertisements