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Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)

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Abstract

Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this article, we report the polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace the current state-of-the-art polymerization of EtOx in acetonitrile and chlorobenzene. This switch towards ethyl acetate as green solvent is an important improvement towards pharmaceutical compliance/compatibility, besides the lower burden for the environment.

Graphical abstract: Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)

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Article information


Submitted
11 Nov 2019
Accepted
28 Jan 2020
First published
03 Feb 2020

Green Chem., 2020, Advance Article
Article type
Paper

Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)

M. Vergaelen, B. Verbraeken, J. F. R. Van Guyse, A. Podevyn, A. Tigrine, V. R. de la Rosa, B. D. Monnery and R. Hoogenboom, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC03872H

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