Jump to main content
Jump to site search


Iron-catalyzed cross-dehydrogenative coupling of indolin-2-ones with active methylenes for direct carbon–carbon double bond formation

Author affiliations

Abstract

The iron-catalyzed cross-dehydrogenative coupling (CDC) of C(sp3)–H/C(sp3)–H bonds to afford olefins by 4H elimination is described. This method employs air (molecular oxygen) as an ideal oxidant, and is performed under mild, ligand-free and base-free conditions. H2O is the only byproduct. Good tolerance of functional groups and high yields have also been achieved. Preliminary mechanistic investigations suggest that the present transformation involves a radical process.

Graphical abstract: Iron-catalyzed cross-dehydrogenative coupling of indolin-2-ones with active methylenes for direct carbon–carbon double bond formation

Back to tab navigation

Supplementary files

Article information


Submitted
23 Oct 2019
Accepted
11 Dec 2019
First published
11 Dec 2019

Green Chem., 2020, Advance Article
Article type
Communication

Iron-catalyzed cross-dehydrogenative coupling of indolin-2-ones with active methylenes for direct carbon–carbon double bond formation

Z. Tan, K. Wu, L. Huang, R. Wu, Z. Du and D. Xu, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC03639C

Social activity

Search articles by author

Spotlight

Advertisements