The salt-free Nickel-Catalysed alpha-Allylation Reaction of Ketones with Allyl Alcohol and Diallylether
The nickel-catalysed alpha-allylation of ketones with allyl alcohol and diallylether has been performed under neutral conditions. As no base is involved, the products are synthesized without salts as side products. The dppf / Ni(cod)2 catalytic system in MeOH at 80°C has been shown as the most performant reaction conditions to afford tetrasubstituted derivatives from various cyclic and acyclic ketones with one or two mobile protons. This process combined with a metathesis step yields spirocyclic compounds according to a salt free synthetic sequence.