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An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis

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Abstract

The first example of an inorganic-ligand supported iron(III) catalysed coupling of formic acid and amines to form formamides is reported. The pure inorganic catalyst (NH4)3[FeMo6O18(OH)6] (1), which consists of a central FeIII single-atomic core supported within a cycle-shaped inorganic ligand consisting of six MoVIO6 octahedra, shows excellent activity and selectivity, and avoids the use of complicated/commercially unavailable organic ligands. Various primary amines and secondary amines have been successfully transformed into the corresponding formamides under mild conditions, and the formylation of primary diamines has also been achieved for the first time. The Fe catalyst 1 can be reused several times without appreciable loss of activity.

Graphical abstract: An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis

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Article information


Submitted
15 Oct 2019
Accepted
16 Dec 2019
First published
19 Dec 2019

Green Chem., 2020, Advance Article
Article type
Paper

An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis

Z. Wu, Y. Zhai, W. Zhao, Z. Wei, H. Yu, S. Han and Y. Wei, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC03564H

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