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Issue 2, 2020
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A palladium-catalyzed oxidative aminocarbonylation reaction of alkynone O-methyloximes with amines and CO in PEG-400

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Abstract

A palladium-catalyzed oxidative aminocarbonylation of O-methyloximes and amines under aerobic conditions with PEG-400 as an environmentally benign medium was accomplished. This novel protocol provides the first straightforward synthetic method for the assembly of structurally diverse 4-carboxamide isoxazoles with high atom- and step-economy and exceptional functional group tolerance. Notably, the employment of ionic liquids as an additive, with air as the sole oxidant, without ligands is an attractive feature of the present approach.

Graphical abstract: A palladium-catalyzed oxidative aminocarbonylation reaction of alkynone O-methyloximes with amines and CO in PEG-400

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Article information


Submitted
15 Oct 2019
Accepted
02 Dec 2019
First published
03 Dec 2019

Green Chem., 2020,22, 465-470
Article type
Paper

A palladium-catalyzed oxidative aminocarbonylation reaction of alkynone O-methyloximes with amines and CO in PEG-400

J. Li, J. Yu, W. Xiong, H. Tang, M. Hu, W. Wu and H. Jiang, Green Chem., 2020, 22, 465
DOI: 10.1039/C9GC03562A

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