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Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing

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Abstract

Thermomechanical engineering of pharmaceutical salts in the solid state using continuous extrusion processing (ssTME) is a new novel manufacturing approach. In the present work, we introduce a paradigm for the synthesis of ketoconazole – oxalic acid and ciprofloxacin – maleic acid salts by imparting temperature, shear rate and stress in comparison to liquid assisted grinding (LAG) approach. We demonstrated that thermomechanical synthesis is advantageous by producing high quality and pure, solvent-free pharmaceutical salts by tailoring extrusion processing variables.

Graphical abstract: Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing

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Article information


Submitted
12 Oct 2019
Accepted
18 Nov 2019
First published
23 Dec 2019

This article is Open Access

Green Chem., 2020, Advance Article
Article type
Paper

Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing

M. S. H. Mithu, S. A. Ross, B. D. Alexander and D. Douroumis, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC03528A

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