Jump to main content
Jump to site search


Cytochrome c-Urea Functionalized Dipeptide Conjugate: An Efficient HBD framework, to synthesize 4H-Pyrans via One-Pot Multicomponent Reaction

Abstract

This work is focused on the development of an efficient and green protocol for the one-pot multicomponent synthesis of a series of 4H-Pyran derivatives. Herein, Protein- Peptideconjugate (SS1-Cyt.c) is synthesized and characterized using Circular Dichroism (CD), UV-Visible absorption spectroscopy and Docking studies. The whole assembly is used as an efficient catalytic system by incorporating a derivatized dipeptide molecule in the hydrophobic cavities of the protein Cytochrome c (Cyt. c) that leads to the activation of Hydrogen Bond Donating (HBD) units of urea derivative of a dipeptide (SS1). The HBD units tend to show non-covalent interaction with the reactant species responsible for triggering the organic transformation to take place. Also, the stability and binding interactions of the SS1-Cyt.c with the multicomponent reactants involved in the organic transformation is studied in detail using MD-Simulation studies. It is a metal-free catalyst and provided higher yield in relatively short reaction time. As per green chemistry premises, the catalyst has provided us ideal Eco-scale and E factor score of 79 and 0.089 respectively.

Back to tab navigation

Supplementary files

Article information


Submitted
10 Oct 2019
Accepted
24 Dec 2019
First published
26 Dec 2019

Green Chem., 2020, Accepted Manuscript
Article type
Paper

Cytochrome c-Urea Functionalized Dipeptide Conjugate: An Efficient HBD framework, to synthesize 4H-Pyrans via One-Pot Multicomponent Reaction

S. Saini, M. ., N. Kaur and N. Singh, Green Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9GC03512E

Social activity

Search articles by author

Spotlight

Advertisements