Jump to main content
Jump to site search


Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium

Author affiliations

Abstract

Visible-light-driven continuous-flow decarboxylative annulation was achieved and used along with a microreactor containing immobilized ruthenium catalyst to construct valuable fused imidazole derivatives with high yields under an open atmosphere. Notably, this chemistry included the use of L-proline and α-azidochalcone as precursors of an α-amino radical and 2H-azirine via photo-induced decarboxylation and denitrogenation, respectively, to give the annulated imidazole derivatives as a result of the formation of two new C–N bonds. Moreover the novel, environmentally benign and efficient continuous-flow protocol was further improved by carrying out the reaction in a polydimethylsiloxane (PDMS) microreactor with immobilized Ru3+ under fluorescent or white LED light, enabling excellent yields (70–94%) at a reaction time (2 min) significantly shorter than that (16 h) of the batch protocol.

Graphical abstract: Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium

Back to tab navigation

Supplementary files

Article information


Submitted
09 Oct 2019
Accepted
06 Feb 2020
First published
06 Feb 2020

Green Chem., 2020, Advance Article
Article type
Communication

Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium

P. R. Adiyala, S. Jang, N. K. Vishwakarma, Y. Hwang and D. Kim, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC03496J

Social activity

Search articles by author

Spotlight

Advertisements