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Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds via visible-light photocatalyst in water

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Abstract

A general and efficient visible-light photoredox-catalysed decarboxylative radical coupling reaction of N-aryl amino acids with aldehydes or ketones for the synthesis of various 1,2-amino alcohols by using water as the solvent at room temperature is described. This protocol is characterised by broad substrate scopes, mild reaction conditions and amenability to gram-scale synthesis, which opens up a simple, mild but effective method to produce 1,2-amino alcohols from readily available starting materials.

Graphical abstract: Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds via visible-light photocatalyst in water

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Article information


Submitted
07 Oct 2019
Accepted
16 Dec 2019
First published
17 Dec 2019

Green Chem., 2020, Advance Article
Article type
Communication

Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds via visible-light photocatalyst in water

S. Pan, M. Jiang, J. Hu, R. Xu, X. Zeng and G. Zhong, Green Chem., 2020, Advance Article , DOI: 10.1039/C9GC03470F

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