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Potential Neuroprotection of Wheat Alkylresorcinols in Hippocampal Neurons via Nrf2/ARE Pathway

Abstract

5-n-alkylresorcinols (ARs) are abundant in wheat bran and potentially antioxidative, although the neuroprotective mechanism is not fully understood. The neuroprotective effect of wheat bran ARs on the H2O2-induced neuronal cells and the relationship between neuroprotection and the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant-response element (ARE) pathway was investigated in this study. Seven homologs were identified in the purified ARs by high-performance liquid chromatography − tandem mass spectrometry. Pre-treatment with 80 μg/mL ARs alleviated 23% HT22 cell death and up-regulation of intracellular reactive oxygen species level and malondialdehyde under the H2O2 stimulation. The neuroprotection was proven by the increase in the Nrf2 nuclear location and up-regulation of mRNA and protein expressions of heme oxygenase-1, NAD(P)H quinone dehydrogenase 1, glutamate-cysteine ligase catalytic subunit, and glutamate-cysteine ligase modifier subunit l. Wheat bran ARs displayed neuroprotective function, possibly by promoting the endogenous antioxidant defense system. ARs may be regarded as a functional food ingredient for preventing neurodegenerative diseases in the future.

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Article information


Submitted
30 Aug 2020
Accepted
12 Oct 2020
First published
13 Oct 2020

Food Funct., 2020, Accepted Manuscript
Article type
Paper

Potential Neuroprotection of Wheat Alkylresorcinols in Hippocampal Neurons via Nrf2/ARE Pathway

F. Fan, Y. Zou, Y. Fang, P. Li, J. Xia, X. Shen, Q. Liu and Q. Hu, Food Funct., 2020, Accepted Manuscript , DOI: 10.1039/D0FO02285C

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