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Potato resistant starch inhibits obesity in mice by up-regulating UCP-1 activity in brown fat through gut microbiota

Abstract

Potato resistant starch (RS) was prepared by microwave-toughening treatment (MTT). This study investigated the beneficial effects of RS on high-fat diet (HFD)-induced hyperlipidemia in C57BL/6J mice by evaluating changes in gut microbiota. Mice were fed low-fat diet with corn starch, HFD with corn starch, HFD with potato starch (HFP), or HFD with RS (HFR) for 6 weeks. Results showed that the HFR group had lower body weight and total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels compared with the HFP group. Moreover, the brown adipose tissue levels of uncoupling protein 1 (UCP-1), β3-adrenoceptor (β3-AR), peroxisome proliferator-activated receptor-γ (PPAR-γ), and PPAR-γ coactivator-1α (PGC-1α) were increased. Our results showed that RS supplementation increased Bacteroidetes/Firmicutes ratio and the abundance of short-chain fatty acid-producing Allobaculum, Ruminococcus, and Blautia. Our data suggest that RS prepared by MTT may be used as a prebiotic agent to prevent gut dysbiosis and obesity-related chronic diseases, such as hyperlipidemia and obesity.

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Supplementary files

Article information


Submitted
08 Aug 2020
Accepted
24 Sep 2020
First published
08 Oct 2020

Food Funct., 2020, Accepted Manuscript
Article type
Paper

Potato resistant starch inhibits obesity in mice by up-regulating UCP-1 activity in brown fat through gut microbiota

Y. Li, W. Liu, Z. Xu, J. Xiao, A. Zong, B. Qiu, M. Jia, L. LIU and T. Xu, Food Funct., 2020, Accepted Manuscript , DOI: 10.1039/D0FO02093A

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