Jackfruit (Artocarpus heterophyllus Lam.) Oligopeptides regulate immune responses via Th cells stimulation, cytokine secretion and antibody production
This study aimed to observe the immunomodulatory effects of oligopeptides derived from Jackfruit (Artocarpus heterophyllus Lam.) (JOPs). 200 female BALB/c mice in five groups were respectively given deionized water (control), whey protein (0.20g/kg body weight (BW)) and JOPs 0.20, 0.40, and 0.80 g/kg BW by intragastric administration on a daily basis. 7 tests were conducted to determine the immunomodulatory effects of JOPs on immune organ indexes, cellular and humoral immune responses, macrophage phagocytosis, and natural killer (NK) cell activity. Spleen T lymphocyte sub-populations, serum cytokine and immunoglobulin levels were tested to study how JOPs improved the immune system. We found that JOPs could significantly enhance innate and adaptive immune responses in mice by the improvement of cell-mediated and humoral immunity, macrophage phagocytosis capacity as well as NK cell activity. The immunomodulatory effects might be based on increased T and Th cell percentages, serum interleukin (IL)-1α, IL-10, tumor necrosis factor (TNF)-α, productions of immunoglobulin (Ig) M, IgG, and IgA as well as depressed interferon (IFN)-γ secretion. These results suggest that dietary JOPs could be valuable as potential immunomodulators.