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Issue 10, 2020
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A novel hypoglycemic agent: polysaccharides from laver (Porphyra spp.)

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Abstract

Type-II diabetes mellitus (T2DM) has become one of the most prevalent diseases on Earth and some treatments have been developed to manage it. One intestinal enzyme α-amylase can break down starch to glucose. Inhibiting its activity will control blood glucose and provide an essential approach for the management of T2DM. Alpha-amylase inhibitor (α-AI) specifically inhibits the activity of α-amylase, and reduces the blood glucose level efficiently. To develop a novel α-AI, the red seaweed laver (Porphyra spp.) was exploited in this work, whose extracts contain polysaccharides showing an inhibitory effect against α-amylase. The crude polysaccharides were extracted using hot water (85 °C) and degraded to low-molecular-weight polysaccharides with 7% of H2O2. One polysaccharide PD-1 exhibiting a competitive binding mode with an IC50 of 12.72 mg mL−1 was separated from these degraded polysaccharides, showing approximately 98.78% of α-amylase inhibition activity. In vivo, PD-1 could efficiently suppress postprandial blood glucose levels in normal and diabetic rats. The polysaccharide inhibitor from red seaweed laver could be regarded as a novel functional food ingredient in T2DM management.

Graphical abstract: A novel hypoglycemic agent: polysaccharides from laver (Porphyra spp.)

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Article information


Submitted
08 May 2020
Accepted
04 Sep 2020
First published
08 Sep 2020

Food Funct., 2020,11, 9048-9056
Article type
Paper

A novel hypoglycemic agent: polysaccharides from laver (Porphyra spp.)

A. Zeng, R. Yang, S. Yu and W. Zhao, Food Funct., 2020, 11, 9048
DOI: 10.1039/D0FO01195A

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