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Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer

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Abstract

Ellagic acid (EA), a natural polyphenol compound that exists in a variety of fruits and vegetables, has been reported to inhibit tumor growth by reducing cell growth, inducing apoptosis, and damaging mitochondria. Recent reports demonstrate that mitochondria regulate cancer cell death through energy metabolism and that different types of cell death coexist in vivo. We showed that EA inhibited lung cancer cell proliferation, markedly decreased ATP levels, decreased the potential of the inner mitochondrial membrane and decreased oxygen consumption in vitro. In addition, EA activated AMP-activated protein kinase (AMPK) and reduced HIF-1α in lung cancer cells. Moreover, the treatment of tumor-bearing mice with EA dramatically inhibited tumor growth, increased p-AMPK and suppressed HIF-1α levels. These findings suggest that EA could be a promising chemotherapeutic agent that targets mitochondrial metabolism in lung cancer.

Graphical abstract: Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer

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Article information


Submitted
06 May 2020
Accepted
26 May 2020
First published
13 Jun 2020

Food Funct., 2020, Advance Article
Article type
Paper

Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer

J. Duan, Y. Li, H. Gao, D. Yang, X. He, Y. Fang and G. Zhou, Food Funct., 2020, Advance Article , DOI: 10.1039/D0FO01177K

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