Jump to main content
Jump to site search


A milk-derived pentapeptide reduces blood pressure in advanced hypertension in a CCK system-dependent manner

Author affiliations

Abstract

We recently found that a peptide that activates the cholecystokinin (CCK) system effectively reduces blood pressure in spontaneously hypertensive rats (SHR) after the development of hypertension, after which hypotensive drugs are sometimes less effective. In this study, we investigated the vasorelaxation and antihypertensive effects of a peptide derived from a milk protein in SHR with advanced hypertension. The vasorelaxing activity was measured using the mesenteric artery isolated from SHR and the systemic blood pressure was measured by the tail-cuff method. KFWGK was released from bovine serum albumin (BSA) and the model peptide after subtilisin digestion. KFWGK relaxed the mesenteric artery and this vasorelaxation activity was inhibited by lorglumide, an antagonist of the CCK1 receptor. KFWGK more potently relaxed the artery from advanced-stage SHR than that from early-stage SHR. Orally administered KFWGK exhibited potent and long-lasting antihypertensive effects in SHR after the development of hypertension (the minimum effective dose was 5 μg kg−1). The KFWGK-induced antihypertensive effects were also blocked by a CCK antagonist, suggesting that it activates the CCK system. In conclusion, KFWGK, a CCK-dependent vasorelaxant peptide, exhibited potent antihypertensive effects in SHR after the development of hypertension.

Graphical abstract: A milk-derived pentapeptide reduces blood pressure in advanced hypertension in a CCK system-dependent manner

Back to tab navigation

Supplementary files

Article information


Submitted
30 Apr 2020
Accepted
18 Sep 2020
First published
22 Sep 2020

Food Funct., 2020, Advance Article
Article type
Communication

A milk-derived pentapeptide reduces blood pressure in advanced hypertension in a CCK system-dependent manner

D. Koyama, M. Sasai, S. Matsumura, K. Inoue and K. Ohinata, Food Funct., 2020, Advance Article , DOI: 10.1039/D0FO01122C

Social activity

Search articles by author

Spotlight

Advertisements