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Issue 5, 2020
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Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

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Abstract

During chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) have well established effects on gene networks that stimulate osteoclastogenesis, which is the culprit of several bone diseases. In this study, we investigated the anti-osteoclastogenic effects in vitro of oleuropein (OL) and its peracetylated derivative (Per-OL) by exploring the expression level of key hub genes involved in fate decision and lineage commitment, differentiation, and function of human blood monocyte-derived osteoclasts. Monocytes were purified from peripheral blood mononuclear cells of healthy individuals using commercial antibodies coated with magnetic beads and treated with M-CSF/RANKL in the presence or absence of OL or Per-OL (25 and 50 μM) for 6 days. We demonstrated that OL and especially Per-OL impair transcriptional gene circuits able to support osteoclastogenesis from human blood monocytes. Our results indicate that OL and notably Per-OL are promising candidates to control osteoclastogenesis.

Graphical abstract: Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

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Article information


Submitted
19 Feb 2020
Accepted
14 Apr 2020
First published
17 Apr 2020

This article is Open Access

Food Funct., 2020,11, 4038-4048
Article type
Paper

Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

M. A. Rosillo, S. Montserrat-de-la-Paz, R. Abia, M. L. Castejon, M. C. Millan-Linares, C. Alarcon-de-la-Lastra, J. G. Fernandez-Bolaños and F. J. G. Muriana, Food Funct., 2020, 11, 4038
DOI: 10.1039/D0FO00433B

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