Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Therapeutic target and molecular mechanism of vitamin C-treated pneumonia: a systematic study of network pharmacology

Author affiliations

Abstract

Vitamin C (VC), a well-reported antioxidant, is found with beneficial actions of preventing and treating pneumonia. However, the detailed pharmacological target and mechanism of VC-treated pneumonia remain unclear. Thus, the present bioinformatics approach using systematic network pharmacology aimed to reveal primary predictive targets, cellular processes, and molecular pathways of VC-treated pneumonia. As shown in bioinformatics assays, the data included 90 primary presumptive targets of VC-treated pneumonia, and 5 other core targets of VC-treated pneumonia were identified as mitogen activated protein kinase 1 (MAPK1), c–c chemokine receptor type 5 (CCR5), mitogen activated protein kinase 3 (MAPK3), angiotensin II type 2 (AT-2) receptor (AGTR2), and signal transducer and activator of transcription 3 (STAT3). In addition, all biological processes (including top 20) and signaling pathways (including top 20) of VC-treated pneumonia were identified and illustrated through bioinformatics analyses. In conclusion, VC-achieved anti-pneumonia effects are mechanically implicated with the suppression of inflammation and enhancement of immunoregulation associated with functional processes and signaling pathways. More interestingly, the identified VC targets may act as biomarkers for the diagnosis and treatment of pneumonia.

Graphical abstract: Therapeutic target and molecular mechanism of vitamin C-treated pneumonia: a systematic study of network pharmacology

Back to tab navigation

Supplementary files

Article information


Submitted
19 Feb 2020
Accepted
26 Apr 2020
First published
27 Apr 2020

Food Funct., 2020, Advance Article
Article type
Paper

Therapeutic target and molecular mechanism of vitamin C-treated pneumonia: a systematic study of network pharmacology

R. Li, C. Guo, Y. Li, X. Liang, L. Yang and W. Huang, Food Funct., 2020, Advance Article , DOI: 10.1039/D0FO00421A

Social activity

Search articles by author

Spotlight

Advertisements