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Issue 4, 2020
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Proteomic landscape of liver tissue in old male mice that are long-term treated with polysaccharides from Sargassum fusiforme

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Abstract

Sargassum fusiforme is a type of brown algae and well known as a longevity promoting vegetable in Northeastern Asia. The polysaccharides derived from Sargassum fusiforme (SFPs) have been suggested as an antioxidant component for anti-aging function. However, global molecular changes in vivo by SFPs have not been fully elucidated. Here, we present a proteomics study using liver tissues of aged male mice that were fed with SFPs. Of forty-nine protein spots, thirty-eight were up-regulated and eleven were down-regulated, showing significant changes in abundance by two-dimensional gel electrophoresis. These differentially expressed proteins were mainly involved in oxidation–reduction, amino acid metabolism, and energy metabolism. Forty-six proteins were integrated into a unified network, with catalase (Cat) at the center. Intriguingly, most of the proteins were speculated as mitochondrial-located proteins. Our findings suggested that SFPs modulated antioxidant enzymes to scavenge redundant free radicals, thus preventing oxidative damage. In conclusion, our study provides a proteomic view on how SFPs have beneficial effects on the aspects of antioxidant and energy metabolism during the aging process. This study facilitates the understanding of anti-aging molecular mechanisms in polysaccharides derived from Sargassum fusiforme.

Graphical abstract: Proteomic landscape of liver tissue in old male mice that are long-term treated with polysaccharides from Sargassum fusiforme

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Supplementary files

Article information


Submitted
20 Jan 2020
Accepted
18 Mar 2020
First published
20 Mar 2020

Food Funct., 2020,11, 3632-3644
Article type
Paper

Proteomic landscape of liver tissue in old male mice that are long-term treated with polysaccharides from Sargassum fusiforme

P. Chen, Y. Zhang, M. Xu, H. Chen, H. Zou, X. Zhang, H. Tong, C. You and M. Wu, Food Funct., 2020, 11, 3632
DOI: 10.1039/D0FO00187B

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