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Dietary intake of Lycium ruthenicum Murray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis

Abstract

In this study, phytochemical compositions of Lycium ruthenicum Murray ethanol extract (LRE) was analyzed by LC-ESI-MS/MS and the protective effect of LRE on inflammatory bowel disease (IBD) was evaluated in dextran sulfate sodium (DSS) induced experimental colitis mice model. Results showed that a total of 129 compounds were tentatively identified, including phenols/phenolic acids, flavonoids and others. LRE supplement significantly reduced DSS-induced body weight loss, disease activity index increase, colon length shortening and colonic pathological damage. LRE inhibited intestinal inflammation by regulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathway, restored intestinal immune homeostasis by regulating immune cells infiltration and T lymphocyte subsets, and suppressed (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation. Moreover, LRE profoundly ameliorated aberrant oxidative stress and restored the intestinal barrier integrity of colitis. Together, LRE supplementation might provide a new dietary strategy for preventing and ameliorating of IBD as a functional food.

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Supplementary files

Article information


Submitted
19 Jan 2020
Accepted
18 Mar 2020
First published
24 Mar 2020

Food Funct., 2020, Accepted Manuscript
Article type
Paper

Dietary intake of Lycium ruthenicum Murray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis

S. Zong, L. Yang, H.J. Park and J. Li, Food Funct., 2020, Accepted Manuscript , DOI: 10.1039/D0FO00172D

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