Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Raspberry extract promoted longevity and stress tolerance via insulin/IGF signaling pathway and DAF-16 in Caenorhabditis elegans

Abstract

Increased consumption of fruits and vegetables is associated with reduced risk of age-related functional decline and chronic diseases, which is primarily attributed to phytochemicals. Raspberries are rich in phytochemicals with a wide range of biological activities and health benefits. However, little is known about their effects on aging. The objective of this study was to determine whether raspberry extract (RE) could promote lifespan and stress resistance on Caenorhabditis elegans (C. elegans), and to explore the underlying mechanisms of action. The results showed that the mean lifespan of C. elegans treated with RE at 20, 40 and 80 mg/mL was significantly increased by 13.6%, 22.9% and 29.7%, respectively, in a dose-dependent manner. Supplementation with RE decreased accumulation of lipofuscin, extended health span of animals including improving motility and enhancing resistance to heat stress and UV-B radiation in C. elegans. Meanwhile, treatment with RE could regulate the expression of anti-aging related genes, including daf-2, age-1, akt-2, sir-2.1, daf-16, skn-1, jnk-1 and hsp-16.2, and promote the migration of DAF-16 into the nucleus. In addition, administration with RE abolished the extension of the lifespan of daf-2(e1370) mutants and RNAi (daf-16) C. elegans, and inhibited the expression of daf-16 downstream gene, including sod-3, ctl-2, dod17 and clk-1. In conclusion, RE could prolong the lifespan, improve health span and enhance stress resistance in C. elegans by the insulin/IGF signaling pathway and DAF-16. Providing the theoretical basis to fully exploit the raspberry in the prevention of aging and health care.

Back to tab navigation

Article information


Submitted
02 Dec 2019
Accepted
27 Feb 2020
First published
28 Feb 2020

Food Funct., 2020, Accepted Manuscript
Article type
Paper

Raspberry extract promoted longevity and stress tolerance via insulin/IGF signaling pathway and DAF-16 in Caenorhabditis elegans

B. Song, B. Zheng, T. Li and R. Liu, Food Funct., 2020, Accepted Manuscript , DOI: 10.1039/C9FO02845E

Social activity

Search articles by author

Spotlight

Advertisements