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Issue 3, 2020
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New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats

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Abstract

Pachira glabra is a medium sized tree that is famous for its delicious edible seeds and leaves. Phytochemical investigation of Pachira glabra leaf alcohol extract led to the isolation of a new γ-pyrone glycoside, 7-hydroxy maltol-3-O-β-D-glucoside (HMGlu). In vivo assessment of the gastro-protective activity of HMGlu demonstrated superior gastro-protection at a dose of 100 mg kg−1, close to the value triggered by the standard reference omeprazole drug (evidenced by morphological and histopathological examinations). This was further confirmed by immunohistochemical staining where pretreatment with HMGlu (100 mg kg−1) markedly reduced NFκB, COX-2 and BAX positively-stained cells. Thus, it can be concluded that 7-hydroxy maltol-3-O-β-D-glucoside can be a new pharmaceutically active agent with promising gastro-protective activity of natural origin.

Graphical abstract: New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats

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Article information


Submitted
26 Nov 2019
Accepted
27 Jan 2020
First published
28 Jan 2020

Food Funct., 2020,11, 1958-1965
Article type
Communication

New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats

M. I. Gamal El-Din, F. S. Youssef, M. L. Ashour, O. A. Eldahshan and A. N. B. Singab, Food Funct., 2020, 11, 1958
DOI: 10.1039/C9FO02800E

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