Jump to main content
Jump to site search


New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using alcohol-induced gastric ulcer model in rats

Abstract

Pachira glabra is a medium sized tree that is famous for its delicious edible seeds and leaves. Phytochemical investigation of Pachira glabra leaf alcohol extract led to the isolation of a new γ-pyrone glycoside; 7-hydroxy maltol-3-O-β-D-glucoside (HMGlu). In vivo assessment of gastro-protective activity of HMGlu demonstrated superior gastro-protection at dose of 100 mg/kg approaching that triggered by standard reference omeprazole drug (evidenced by morphological and histopathological examination. This was further confirmed by immunohistochemical staining where pretreatment with HMGlu (100 mg/kg) markedly reduced NFкB, COX-2 and BAX positively-stained. Thus, it can be concluded that 7-hydroxy maltol-3-O-β-D-glucoside can offer a new pharmaceutically active agent with promising gastro-protective activity of natural origin.

Back to tab navigation

Supplementary files

Article information


Submitted
26 Nov 2019
Accepted
27 Jan 2020
First published
28 Jan 2020

Food Funct., 2020, Accepted Manuscript
Article type
Communication

New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using alcohol-induced gastric ulcer model in rats

M. Gamal El-Din, F. S. Youssef, M. Ashour, O. Eldahshan and A. B. Singab, Food Funct., 2020, Accepted Manuscript , DOI: 10.1039/C9FO02800E

Social activity

Search articles by author

Spotlight

Advertisements