New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using alcohol-induced gastric ulcer model in rats
Pachira glabra is a medium sized tree that is famous for its delicious edible seeds and leaves. Phytochemical investigation of Pachira glabra leaf alcohol extract led to the isolation of a new γ-pyrone glycoside; 7-hydroxy maltol-3-O-β-D-glucoside (HMGlu). In vivo assessment of gastro-protective activity of HMGlu demonstrated superior gastro-protection at dose of 100 mg/kg approaching that triggered by standard reference omeprazole drug (evidenced by morphological and histopathological examination. This was further confirmed by immunohistochemical staining where pretreatment with HMGlu (100 mg/kg) markedly reduced NFкB, COX-2 and BAX positively-stained. Thus, it can be concluded that 7-hydroxy maltol-3-O-β-D-glucoside can offer a new pharmaceutically active agent with promising gastro-protective activity of natural origin.