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Protective effect of Lachnum polysaccharide on dextran sulfate sodium-induced colitis in mice

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Abstract

Inflammatory bowel disease (IBD) has been gradually considered as a public health challenge worldwide. This study determined the protective effect of Lachnum polysaccharide (LEP) on dextran sulfate sodium (DSS)-induced experimental colitis in mice and explored the underlying mechanism. Results showed that dietary LEP reduced DSS-induced disease activity index (DAI), colon shortening and colonic tissue damage. LEP treatment restored intestinal barrier integrity by regulating the expression of tight junction proteins and mucus layer protecting proteins. Moreover, pro-inflammatory cytokine production was inhibited by LEP through regulating PPARγ/NF-κB and IL-6/STAT3 pathways and inhibiting inflammatory cell infiltration. In addition, LEP also inhibited (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, endoplasmic reticulum (ER) stress and oxidative/nitrosative stress induced by DSS. These results provided a scientific basis for LEP as a potential natural agent for protecting mice from DSS-induced IBD.

Graphical abstract: Protective effect of Lachnum polysaccharide on dextran sulfate sodium-induced colitis in mice

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Article information


Submitted
19 Nov 2019
Accepted
30 Dec 2019
First published
10 Jan 2020

Food Funct., 2020, Advance Article
Article type
Paper

Protective effect of Lachnum polysaccharide on dextran sulfate sodium-induced colitis in mice

S. Zong, Z. Ye, X. Zhang, H. Chen and M. Ye, Food Funct., 2020, Advance Article , DOI: 10.1039/C9FO02719J

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