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The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that commonly occurs among older individuals. Increasing evidence suggests that a low-caloric diet might be a promising adjuvant therapeutic strategy for slowing or preventing the pathogenesis and progression of AD through the induction of autophagy. Several intracellular pathways have been implicated in caloric restriction (CR)-induced autophagy. In this review, we summarized the efficacy of CR as well as its mimetics (resveratrol, spermidine, aspirin, rapamycin, metformin, and curcumin) in improving cognitive function of rodent models of AD. On the basis of recent in vitro and animal studies, the beneficial effects of CR- or caloric restriction mimetics-induced autophagy in alleviating amyloid burden and tau pathology of AD were also discussed.

Graphical abstract: The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

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Article information


Submitted
07 Nov 2019
Accepted
12 Feb 2020
First published
13 Feb 2020

Food Funct., 2020, Advance Article
Article type
Review Article

The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

Y. Yang and L. Zhang, Food Funct., 2020, Advance Article , DOI: 10.1039/C9FO02611H

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