Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Enhancement of the cancer inhibitory effect of the bioactive food component resveratrol by nanoparticle based delivery

Author affiliations

Abstract

Naturally occurring bioactive food components such as dietary polyphenols have shown many beneficial biological activities due to their good antioxidant properties. Among them significant attention has been given to resveratrol (RV) in recent years as it plays a promising role in cancer prevention. It has demonstrated anti-proliferative effects, as well as the ability to inhibit the initiation and progression of induced cancer in a wide variety of tumor models. However, the benefits of its therapeutic effects were found to be limited due to its poor pharmacokinetic properties such as poor aqueous solubility, instability and extensive first pass metabolism. To overcome these limitations, the present study aimed to synthesize thermosensitive copolymeric nanoparticle encapsulated formulations of resveratrol–nanoresveratrol (NRV) and evaluate their in vitro anticancer activity and inhibitory effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin inflammation and tumorigenesis in Swiss albino mice. For this purpose PNIPAAM-PEG based thermosensitive copolymeric nanoparticles were synthesized followed by the encapsulation of RV in their hydrophobic core. This enhanced the therapeutic bioavailability of resveratrol. Nanoresveratrol demonstrated stronger antioxidant activity and comparable anticancer efficacy to free resveratrol. Nanoparticles were characterized by IR, NMR, DLS and TEM. The best results were obtained with NRV at significantly lower doses. NRV demonstrated better in vitro anticancer activity against melanoma cell line B16. It showed comparable reduction of TPA induced skin edema, hyperplasia and oxidative stress response. In the promotion phase, a significant reduction was found in tumor incidence and tumor burden in mice pre-treated with NRV. Moreover, at all doses NRV altered Bax and Bcl2 expressions which lead to the induction of apoptosis.

Graphical abstract: Enhancement of the cancer inhibitory effect of the bioactive food component resveratrol by nanoparticle based delivery

Back to tab navigation

Article information


Submitted
18 Oct 2019
Accepted
23 Feb 2020
First published
26 Feb 2020

Food Funct., 2020, Advance Article
Article type
Paper

Enhancement of the cancer inhibitory effect of the bioactive food component resveratrol by nanoparticle based delivery

S. Bano, F. Ahmed, F. Khan, S. C. Chaudhary and M. Samim, Food Funct., 2020, Advance Article , DOI: 10.1039/C9FO02445J

Social activity

Search articles by author

Spotlight

Advertisements