Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Theoretical and experimental investigation of the antioxidative activity of monascin

Author affiliations

Abstract

Monascin, a specific type of monascus pigments, exhibits many bioactivities. In this study, the antioxidative activity of monascin was investigated by theoretical and experimental methods. First, the antioxidant potential of six monascus pigments was predicted by density functional theory (DFT) and time-dependent density functional theory (TDDFT) at the B3LYP/6-31+G (d, p) level, and monascus yellow pigments were predicted to have strong antioxidant capacity, as they can transfer hydrogen to free radicals and accept electrons from radicals. Then, the free radical-scavenging capacity of monascin for 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide, and hydroxyl radicals was experimentally validated by electron spin resonance (ESR) measurement. Monascin exhibited a quenching effect on DPPH, superoxide, and hydroxyl radicals in a dose-dependent manner. Specifically, the scavenging activity of monascin for DPPH, superoxide, and hydroxyl radicals was 97.5%, 59.5%, and 68.6%, respectively, when 0.1 mg mL−1 monascin was present. Our study provides theoretical evidence for the strong antioxidative activity of monascin and offers a simple and reliable strategy to determine the antioxidative activity.

Graphical abstract: Theoretical and experimental investigation of the antioxidative activity of monascin

Back to tab navigation

Article information


Submitted
15 Oct 2019
Accepted
25 May 2020
First published
01 Jun 2020

Food Funct., 2020, Advance Article
Article type
Paper

Theoretical and experimental investigation of the antioxidative activity of monascin

X. Zhang, C. Liu, W. Tian, H. Zhang, P. Li, J. Wang and W. He, Food Funct., 2020, Advance Article , DOI: 10.1039/C9FO02410G

Social activity

Search articles by author

Spotlight

Advertisements