Self-emulsifying formulation of Sonchus oleraceus Linn for improved anti-diabteic effect in vivo
The aim of the present study was to develop a self-emulsifying drug delivery system (SEDDS) containing the extract of S oleraceus Linn (SOL) with improved intestinal stability in order to increase oral bio-potency. SOL was effectively incorporated into emulsions and resistance to in vitro digestion without any destruction of its phenolic acids, glycosides and aglycone. SEDDS and SOL were also prepared for comparison purposes of in vivo anti-diabetic effects. Four weeks of daily treatment of SEDDS dramatically improved the quality of life for diabetic rat. Streptozocin (STZ) caused body weight reduction, which is reversed by SEDDS at low dose (100 mg/kg), is more effectively than SOL at high dose (200 mg/kg). SEDDS also improved the response to glucose tolerance which is significant higher than SOL. On the basis of these findings, the SEDDS approach might be an efficacious dosage option to enhance the nutraceutical properties of SOL.