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Issue 5, 2020
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Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles

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Abstract

The impact on human health of long-term exposure to low doses of silver nanoparticles (AgNPs) remains understudied. Cellular studies have shown the intracellular dissolution of AgNPs within endolysosomes followed by Ag(I) binding to biomolecular thiolate-containing molecules. However, the precise subcellular distribution of Ag(I) and the nature of the disrupted physiological pathways remained unknown. Novel imaging approaches enabled us to visualize the trafficking of AgNP-containing lysosomes towards a perinuclear location and a nuclear transfer of Ag(I) species with accumulation in the nucleoli. These Ag(I) species impaired nuclear receptor activity, disrupting critical mechanisms of liver physiology in low dose exposure scenarios, thus justifying further research into defining a framework for the safe use of AgNPs.

Graphical abstract: Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles

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Supplementary files

Article information


Submitted
27 Nov 2019
Accepted
01 Apr 2020
First published
09 Apr 2020

This article is Open Access

Environ. Sci.: Nano, 2020,7, 1373-1387
Article type
Paper

Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles

V. Tardillo Suárez, E. Karepina, M. Chevallet, B. Gallet, C. Cottet-Rousselle, P. Charbonnier, C. Moriscot, I. Michaud-Soret, W. Bal, A. Fuchs, R. Tucoulou, P. Jouneau, G. Veronesi and A. Deniaud, Environ. Sci.: Nano, 2020, 7, 1373
DOI: 10.1039/C9EN01348B

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