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Underlying mechanisms of reactive oxygen species and oxidative stress photoinduced by graphene and its surface-functionalized derivatives

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Abstract

Graphene can be modified by different functional groups through various transformation processes in the environment. The toxicological activity of graphene is closely related to its ability to produce reactive oxygen species (ROS), which can be altered by surface modification. Herein, unfunctionalized graphene (u-G), carboxylated graphene (G-COOH) and aminated graphene (G-NH2) were selected to determine their ability to photogenerate ROS in the aqueous phase. Oxidative stress (ROS concentration and superoxide dismutase activity) in Daphnia magna under simulated sunlight radiation induced by the materials was also investigated. Based on density functional theory (DFT) calculations, the photochemical pathways of ROS production were identified. G-COOH and G-NH2 produced singlet oxygen in the aqueous phase by mediating energy transfer. G-COOH, G-NH2 and u-G generated superoxide anions and further produced hydroxyl radicals by inducing electron transfer. By comparing the biological redox potential and the lowest occupied molecular orbital values (ELUMO) of the substances, u-G and G-COOH were identified to have the potential to induce oxidative stress. The predictive results were validated by the significant increase of oxidative stress biomarkers in Daphnia magna. By coupling experimental observations with the theoretical predictions, the results provide mechanistic insight into understanding the photochemical activity and toxicity of graphene and its surface-functionalized derivatives.

Graphical abstract: Underlying mechanisms of reactive oxygen species and oxidative stress photoinduced by graphene and its surface-functionalized derivatives

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Article information


Submitted
14 Nov 2019
Accepted
02 Feb 2020
First published
04 Feb 2020

Environ. Sci.: Nano, 2020, Advance Article
Article type
Paper

Underlying mechanisms of reactive oxygen species and oxidative stress photoinduced by graphene and its surface-functionalized derivatives

H. Yao, Y. Huang, X. Li, X. Li, H. Xie, T. Luo, J. Chen and Z. Chen, Environ. Sci.: Nano, 2020, Advance Article , DOI: 10.1039/C9EN01295H

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