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A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity and implications for human health

Abstract

Neonicotinoid insecticides are widely used in both urban and agricultural settings around the world. Historically, neonicotinoid insecticides have been viewed as ideal replacements for more toxic compounds, like organophosphates, due in part to their perceived limited potential to affect the environment and human health. This critical review investigates the environmental fate and toxicity of neonicotinoids and their metabolites and the potential risks associated with exposure. Neonicotinoids are found to be ubiquitous in the environment, drinking water, and food, with low-level exposure commonly documented below acceptable daily intake standards. Available toxicological data from animal studies indicate possible genotoxicity, cytotoxicity, impaired immune function, and reduced growth and reproductive success at low concentrations, while limited data from ecological or cross-sectional epidemiological studies have identified acute and chronic health effects ranging from acute respiratory, cardiovascular, and neurological symptoms to oxidative genetic damage and birth defects. Due to the heavy use of neonicotinoids and potential for cumulative chronic exposure, these insecticides represent novel risks and necessitate further study to fully understood their risks to humans.

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Supplementary files

Article information


Submitted
13 Dec 2019
Accepted
18 Mar 2020
First published
19 Mar 2020

Environ. Sci.: Processes Impacts, 2020, Accepted Manuscript
Article type
Critical Review

A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity and implications for human health

D. A. Thompson, H. Lehmler, D. Kolpin, M. L. Hladik, J. Vargo, K. Schilling, G. H. LeFevre, T. Peeples, M. C. Poch, L. E. LaDuca, D. M. Cwiertny and R. W. Field, Environ. Sci.: Processes Impacts, 2020, Accepted Manuscript , DOI: 10.1039/C9EM00586B

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