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Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies

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Abstract

The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.

Graphical abstract: Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies

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Article information


Submitted
23 Sep 2020
Accepted
30 Sep 2020
First published
07 Oct 2020

Dalton Trans., 2020, Advance Article
Article type
Paper

Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies

N. Guidolin, F. Travagin, G. B. Giovenzana, A. Vágner, S. Lotti, F. Chianale, E. Brücher, F. Maisano, M. A. Kirchin, F. Tedoldi, A. Giorgini, S. Colombo Serra and Z. Baranyai, Dalton Trans., 2020, Advance Article , DOI: 10.1039/D0DT03314F

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