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An octabrominated Sn(iv) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications

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Abstract

Two novel Sn(IV) tetraisopropylphenylporphyrins have been synthesized to explore the effect of octabromination at the β-pyrrole positions on their photophysical properties and photodynamic activity. The lower energy Q band of an octabrominated complex lies at 675 nm well within the therapeutic window. The octabrominated dye has a relatively high singlet oxygen quantum yield of 0.78 in DMF and exhibits favorable photodynamic activity against MCF-7 cells with an IC50 value of 10.7 μM and a 5.74 log reduction value (5 μM) towards S. aureus under illumination at 660 nm for 60 min with a Thorlabs M660L3 LED (280 mW cm−2).

Graphical abstract: An octabrominated Sn(iv) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications

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Supplementary files

Article information


Submitted
28 May 2020
Accepted
18 Jun 2020
First published
18 Jun 2020

Dalton Trans., 2020, Advance Article
Article type
Communication

An octabrominated Sn(IV) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications

B. Babu, J. Mack and T. Nyokong, Dalton Trans., 2020, Advance Article , DOI: 10.1039/D0DT01915A

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