Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 27, 2020
Previous Article Next Article

Microenvironment-sensitive iridium(iii) complexes for disease theranostics

Author affiliations

Abstract

Microenvironmental parameters, including hypoxia, pH, polarity, viscosity and temperature, play pivotal roles in controlling the biological, physical or chemical behaviors of local molecules. Abnormal changes in these parameters would cause cellular malfunction or become a hallmark of the occurrence of severe diseases. Recently, a number of phosphorescent Ir(III) complexes have been designed to respond to such parameters due to their attractive properties such as high photostability, long emission lifetimes, and environment-sensitive emission profiles. This review aims to provide a summary of the progress achieved in developing iridium-based probes responding to microenvironmental parameters in biological systems in recent years for diagnosis and treatment of diseases such as cancer and diabetes.

Graphical abstract: Microenvironment-sensitive iridium(iii) complexes for disease theranostics

Back to tab navigation

Article information


Submitted
20 Apr 2020
Accepted
28 May 2020
First published
28 May 2020

Dalton Trans., 2020,49, 9182-9190
Article type
Perspective

Microenvironment-sensitive iridium(III) complexes for disease theranostics

N. Lu, Y. Luo, Q. Zhang and P. Zhang, Dalton Trans., 2020, 49, 9182
DOI: 10.1039/D0DT01444C

Social activity

Search articles by author

Spotlight

Advertisements