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Issue 27, 2020
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Microenvironment-sensitive iridium(iii) complexes for disease theranostics

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Microenvironmental parameters, including hypoxia, pH, polarity, viscosity and temperature, play pivotal roles in controlling the biological, physical or chemical behaviors of local molecules. Abnormal changes in these parameters would cause cellular malfunction or become a hallmark of the occurrence of severe diseases. Recently, a number of phosphorescent Ir(III) complexes have been designed to respond to such parameters due to their attractive properties such as high photostability, long emission lifetimes, and environment-sensitive emission profiles. This review aims to provide a summary of the progress achieved in developing iridium-based probes responding to microenvironmental parameters in biological systems in recent years for diagnosis and treatment of diseases such as cancer and diabetes.

Graphical abstract: Microenvironment-sensitive iridium(iii) complexes for disease theranostics

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Article information

20 Apr 2020
28 May 2020
First published
28 May 2020

Dalton Trans., 2020,49, 9182-9190
Article type

Microenvironment-sensitive iridium(III) complexes for disease theranostics

N. Lu, Y. Luo, Q. Zhang and P. Zhang, Dalton Trans., 2020, 49, 9182
DOI: 10.1039/D0DT01444C

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