Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Ru(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer

Author affiliations

Abstract

Six new ruthenium(II) complexes with lapachol (Lap) and lawsone (Law) with the general formula [Ru(L)(P–P)(bipy)]PF6, where L = Lap or Law, P–P = 1,2′-bis(diphenylphosphino)ethane (dppe), 1,4′-bis(diphenylphosphino)butane (dppb), 1,1′-bis(diphenylphosphino)ferrocene (dppf) and bipy = 2,2′-bipyridine, were synthesized, fully characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV-vis, IR spectroscopies and three of them by X-ray crystallography. All six complexes were active against breast (MCF-7 and MDA-MB-231) and prostate (DU-145) cancer cell lines with lower IC50 values than cisplatin. Complex [Ru(Lap)(dppe)(bipy)]PF6 (1a) showed significant selectivity for MDA-MB-231, a model of triple-negative breast cancer (TNBC), as compared to the “normal-like” human breast epithelial cell line, MCF-10A. Complex (1a) inhibited TNBC colony formation and induced loss of cellular adhesion. Furthermore, the complex (1a) induced mitochondrial dysfunction and generation of ROS, as is involved in the apoptotic cell death pathway. Preferential cellular uptake of complex (1a) was observed in MDA-MB-231 cells compared to MCF-10A cells, consistent with the observed selectivity for tumorigenic vs. non-tumorigenic cells. Taken together, these results indicate that ruthenium complexes containing lapachol and lawsone as ligands are promising candidates as chemotherapeutic agents.

Graphical abstract: Ru(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer

Back to tab navigation

Supplementary files

Article information


Submitted
23 Mar 2020
Accepted
10 Apr 2020
First published
13 Apr 2020

Dalton Trans., 2020, Advance Article
Article type
Paper

Ru(II)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer

K. M. Oliveira, E. J. Peterson, M. C. Carroccia, M. R. Cominetti, V. M. Deflon, N. P. Farrell, A. A. Batista and R. S. Correa, Dalton Trans., 2020, Advance Article , DOI: 10.1039/D0DT01091J

Social activity

Search articles by author

Spotlight

Advertisements