Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 22, 2020
Previous Article Next Article

Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging

Author affiliations

Abstract

Fluorescent Si-rhodamines were modified to enable complexation with the Re(I)- and 99mTc(I)-tricarbonyl core. The corresponding complexes exhibit suitable properties as bimodal imaging probes for SPECT- and optical imaging in vitro. Importantly, the novel in- aqueous-solution-stable, functionalized Si-rhodamines retain favourable optical properties after complexation (QY = 0.09, λabs = 654 nm, λem = 669 nm in PBS) and show promising near-infrared optical properties for potential in vivo applications enabling bimodal scintigraphic imaging and optical imaging, e.g. used in radio- and fluorescence-guided tumour resection.

Graphical abstract: Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging

Back to tab navigation

Supplementary files

Article information


Submitted
23 Mar 2020
Accepted
08 May 2020
First published
08 May 2020

Dalton Trans., 2020,49, 7294-7298
Article type
Communication

Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging

T. Kanagasundaram, C. S. Kramer, E. Boros and K. Kopka, Dalton Trans., 2020, 49, 7294
DOI: 10.1039/D0DT01084G

Social activity

Search articles by author

Spotlight

Advertisements