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Bioinspired design of an artificial peroxidase: introducing key residues of native peroxidases into F43Y myoglobin with a Tyr-heme cross-link

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Abstract

Inspired by the structural features of native peroxidases, an artificial peroxidase was rationally designed using F43Y myoglobin with a Tyr-heme cross-link by further introduction of key residues, including both a distal Arg and a Trp close to the heme group, which exhibits an enhanced peroxidase activity similar to the most efficient native horseradish peroxidase. This study provides a simple approach for design of artificial heme enzymes by the combination of catalytic elements of native enzymes with the post-translational modifications of heme proteins.

Graphical abstract: Bioinspired design of an artificial peroxidase: introducing key residues of native peroxidases into F43Y myoglobin with a Tyr-heme cross-link

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Article information


Submitted
09 Mar 2020
Accepted
23 Mar 2020
First published
24 Mar 2020

Dalton Trans., 2020, Advance Article
Article type
Communication

Bioinspired design of an artificial peroxidase: introducing key residues of native peroxidases into F43Y myoglobin with a Tyr-heme cross-link

F. Liao, J. Xu, J. Luo, S. Gao, X. Wang and Y. Lin, Dalton Trans., 2020, Advance Article , DOI: 10.1039/D0DT00875C

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