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Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand

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Abstract

Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Upon cellular internalization, Pt-ATRA exhibits a dual function, releasing an active Pt(II) moiety to induce cell apoptosis and ATRA to inhibit tumor metastasis.

Graphical abstract: Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand

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Article information


Submitted
11 Feb 2020
Accepted
20 Mar 2020
First published
24 Mar 2020

Dalton Trans., 2020, Advance Article
Article type
Communication

Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand

Y. Dai, H. Huang, Y. Zhu, J. Cheng, A. Shen and Y. Liu, Dalton Trans., 2020, Advance Article , DOI: 10.1039/D0DT00507J

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