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Dimerization of terminal alkynes promoted by a heterobimetallic Zr/Co complex

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Abstract

Enynes are important synthetic intermediates that are also found in a variety of natural products and other biologically relevant molecules. The most atom economical synthetic route to enynes is via the direct coupling of readily available terminal alkyne precursors. Towards this goal, we demonstrate the formation of 1,3-enynes from terminal alkynes facilitated by a reduced ZrIV/Co−I heterobimetallic complex. An intermediate is trapped as a tBuNC adduct, revealing that bimetallic activation of the terminal C–H bond of the alkyne is an essential mechanistic step.

Graphical abstract: Dimerization of terminal alkynes promoted by a heterobimetallic Zr/Co complex

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Article information


Submitted
29 Jan 2020
Accepted
31 Jan 2020
First published
31 Jan 2020

Dalton Trans., 2020, Advance Article
Article type
Communication

Dimerization of terminal alkynes promoted by a heterobimetallic Zr/Co complex

J. W. Beattie, C. Wang, H. Zhang, J. P. Krogman, B. M. Foxman and C. M. Thomas, Dalton Trans., 2020, Advance Article , DOI: 10.1039/D0DT00334D

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