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Selective Detection of Sulfide in Human Lung Cancer Cells with blue-fluorescence “ON-OFF-ON” Benzimidazole-based Chemosensor Ensemble

Abstract

A completely water-soluble, high quantum yield blue-fluorescent benzimidazole derivative (AQ), containing a rigid benzimidazole-thiophene structure, was synthesized. Among 21 metal ions, the fluorescence of AQ was selectively turned off by Cu2+ to form an AQ-Cu2+ ensemble. Thereby, the fluorescence of AQ-Cu2+ ensemble was turned on by sulfide (S2–) with high selectivity and sensitivity in pure water solution. By compasion to AQ-Ag+ and AQ-Hg2+ ensembles, AQ-Cu2+ was the only ensemble that capable for the detection of sulfide anion. Also, the fluorescence intensity of AQ was linearly proportional to the concentration of Cu2+ and S2–. Both Cu2+ and S2– were detected within a minute in vitro. Moreover, AQ also worked best in the range of pH 5–10 and had a limit of detection of 50 nM and 354 nM for Cu2+ and S2– respectively. It was employed for the detection of sulfide in human lung cancer A549 cells with low cytotoxicity.

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Supplementary files

Article information


Submitted
04 Jan 2020
Accepted
17 Mar 2020
First published
17 Mar 2020

Dalton Trans., 2020, Accepted Manuscript
Article type
Paper

Selective Detection of Sulfide in Human Lung Cancer Cells with blue-fluorescence “ON-OFF-ON” Benzimidazole-based Chemosensor Ensemble

C. Kwan, T. Wang, S. Chan, Z. Cai and K. C. F. Leung, Dalton Trans., 2020, Accepted Manuscript , DOI: 10.1039/D0DT00031K

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