Lanthanide-conjugates as versatile instruments for therapy and diagnostics
Lanthanides have demonstrated their outstanding properties in many fields of research including biology and medicinal chemistry. Unique luminescence and magnetic properties renders them the metals of choice for next generation theranostics that efficiently combine the two central pillars of medicine - diagnostics and therapy. Attached to targeting units, lanthanide complexes pave the way for real-time imaging of uptake and distribution as well as specific regulation of subcellular processes poor in side effects. This enables individualized treatment options of severe diseases characterized by alternated cell expression. The highly diverse efforts achieved as well as insights into the challenges that research has to face in upcoming years will be summarized in the present review.