TiO2/Cu2O nanoparticles – catalyzed direct C(sp)-P bond formation via aerobic oxidative coupling under air and visible light
Synthesis of organophosphorus compounds is one of the important goal in organic chemistry. Among them, alkynylphosphonates are greatly utilized as the main precursors for the synthesis of biologically active molecules in medicinal chemistry and they have extremely interested in past decades. Among a few efforts for direct and atom economy synthesis of alkynylphosphonates, there is no report using visible light as a green and renewable energy. Here, we promote a strategy to construct a type of nano metal oxide composite photocatalyst (Cu2O decorated on TiO2) for the synthesis of alkynylphosphonates via direct C-P bond formation between terminal alkyne and H-phosphonate, under visible light irradiation. In this p-n heterojunction photocatalyst, Cu2O assisted as visible light absorbers, and at the same time CB (conduction bond) of TiO2 is favorable for accepting photogenerated electron and electrony hole (e-/h+) generated could initiate the reaction. This study could develop a new way for the synthesis of this important class of phosphorus organic compounds.