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A study to develop platinum(iv) complex chemistry for peptide disulfide bond formation

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Abstract

Platinum(IV) complexes with a heterocyclic ligand and an ancillary ligand have been investigated and applied for treating various tumour cell lines. Another application of the Pt(IV) complexes in forming peptide disulfide bonds was investigated in this work. For development of Pt(IV) complex chemistry for disulfide bond formation in peptides, two Pt(IV) complexes, [PtCl2(phen)(en)]Cl2 and [PtCl2(bpy)(en)]Cl2, were synthesized and characterized using elemental analysis, ESI-MS and NMR. Subsequently, they were investigated as oxidants for the formation of disulfide bonds in various peptides. Excellent purities and yields of disulfide-containing peptides were achieved when the reactions were carried out in aqueous solution. The reactions were completed rapidly in a wide range of pH values even in acidic medium at room temperature. An intramolecular disulfide bond was formed in each of the peptides in a solution containing two dithiol-containing peptides, making the Pt(IV) complexes useful for generating disulfide-containing peptide libraries. In addition, the two Pt(IV) complexes can be used as oxidants for the synthesis of disulfide bonds on a resin, which is a more convenient method to synthesize disulfide-containing peptides through automation.

Graphical abstract: A study to develop platinum(iv) complex chemistry for peptide disulfide bond formation

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Article information


Submitted
13 Dec 2019
Accepted
15 Jan 2020
First published
15 Jan 2020

Dalton Trans., 2020, Advance Article
Article type
Communication

A study to develop platinum(IV) complex chemistry for peptide disulfide bond formation

C. Song, J. Sun, X. Zhao, S. Huo and S. Shen, Dalton Trans., 2020, Advance Article , DOI: 10.1039/C9DT04738G

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