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Issue 7, 2020
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Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

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Abstract

A superoxide dismutase mimic (Mn1) was functionalized with three positively charged-peptides: RRRRRRRRR (Mn1-R9), RRWWWRRWRR (Mn1-RW9) or Fx-r-Fx-K (Mn1-MPP). Characterization of the physico-chemical properties of the complexes show that they share similar binding affinity for Mn2+, apparent reduction potential and intrinsic superoxide dismutase activity. However, their accumulation in cells is different (Mn1-R9 < Mn1-MPP < Mn1-RW9 < Mn1), as well as their subcellular distribution. In addition, the three functionalized-complexes display a better anti-inflammatory activity than Mn1 when assayed at 10 μM. This improvement is due to a combination of an anti-inflammatory effect of the peptidyl moiety itself, and of the SOD mimic for Mn1-RW9 and Mn1-MPP. In contrast, the enhanced anti-inflammatory activity of Mn1-R9 is solely due to the SOD mimic.

Graphical abstract: Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

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Article information


Submitted
03 Dec 2019
Accepted
29 Jan 2020
First published
29 Jan 2020

Dalton Trans., 2020,49, 2323-2330
Article type
Paper

Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

E. Mathieu, A. Bernard, H. Y. V. Ching, A. Somogyi, K. Medjoubi, J. R. Fores, H. C. Bertrand, A. Vincent, S. Trépout, J. Guerquin-Kern, A. Scheitler, I. Ivanović-Burmazović, P. Seksik, N. Delsuc and C. Policar, Dalton Trans., 2020, 49, 2323
DOI: 10.1039/C9DT04619D

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