Jump to main content
Jump to site search


Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

Author affiliations

Abstract

A superoxide dismutase mimic (Mn1) was functionalized with three positively charged-peptides: RRRRRRRRR (Mn1-R9), RRWWWRRWRR (Mn1-RW9) or Fx-r-Fx-K (Mn1-MPP). Characterization of the physico-chemical properties of the complexes show that they share similar binding affinity for Mn2+, apparent reduction potential and intrinsic superoxide dismutase activity. However, their accumulation in cells is different (Mn1-R9 < Mn1-MPP < Mn1-RW9 < Mn1), as well as their subcellular distribution. In addition, the three functionalized-complexes display a better anti-inflammatory activity than Mn1 when assayed at 10 μM. This improvement is due to a combination of an anti-inflammatory effect of the peptidyl moiety itself, and of the SOD mimic for Mn1-RW9 and Mn1-MPP. In contrast, the enhanced anti-inflammatory activity of Mn1-R9 is solely due to the SOD mimic.

Graphical abstract: Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

Back to tab navigation

Supplementary files

Article information


Submitted
03 Dec 2019
Accepted
29 Jan 2020
First published
29 Jan 2020

Dalton Trans., 2020, Advance Article
Article type
Paper

Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides

E. Mathieu, A. Bernard, H. Y. V. Ching, A. Somogyi, K. Medjoubi, J. R. Fores, H. C. Bertrand, A. Vincent, S. Trépout, J. Guerquin-Kern, A. Scheitler, I. Ivanović-Burmazović, P. Seksik, N. Delsuc and C. Policar, Dalton Trans., 2020, Advance Article , DOI: 10.1039/C9DT04619D

Social activity

Search articles by author

Spotlight

Advertisements